A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61K 31/404 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2483162
This invention discloses and claims substituted 3-amino-2-carboxylic acid indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
L'invention concerne des dérivés d'indole et de benzo(b)thiophène d'acide carboxylique substitué 3-amino-2, utilisés dans le traitement des allergies, de l'asthme, de la rhinite, de la dermatite, des lymphomes des cellules B, des tumeurs et des maladies associées aux infections bactériennes, par rhinovirus ou virus respiratoire syncytial (RSV). Dans des modes de réalisation préférés, l'invention concerne également la capacité des composés de l'invention de moduler les lymphocytes T auxiliaires (Th), Th1/Th2, pouvant ainsi inhiber la transcription du message, de la libération ou de la production de l'interleukine-4 (IL-4).
Alkan Sefik S.
Dinerstein Robert J.
Hrib Nicholas J.
Jurcak John G.
Subramaniam Arun
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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