Use of...

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A - Human Necessities

61

K

A61K 31/335 (2006.01) A61P 27/02 (2006.01) A61P 43/00 (2006.01) C07D 313/12 (2006.01)

Patent

CA 2306393

Ophthalmic formulations containing as an active ingredient 11-(3- dimethylaminopropylidene) -6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.

Des formulations ophtalmiques contenant en tant que principe actif de l'acide 11-(3-diméthylaminopropylidène) -6,11-dihydrodibenz POUND b,e]oxépin-2-acétique ou un sel pharmaceutique acceptable de celui-ci sont utiles pour empêcher la libération de cytokine (par exemple, IL-6 et IL-8) par les cellules oculaires humaines. Ces formulations peuvent être utilisées pour traiter ou prévenir la néoformation de vaisseaux sanguins oculaires et les troubles inflammatoires non allergiques tels que l'oeil sec, la kératite, la blépharite, l'uvéite et l'inflammation associée à l'infection.

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