Use of 4,5-dihydro-1h-pyrazole derivatives having...

A - Human Necessities – 61 – K

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A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4439 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2537090

The present invention relates to a novel medical use of 4,5-dihydro-1H- pyrazole compounds which are potent antagonists of the cannabis CB1-receptor. Said compounds are particularly suitable in the manufacture of medicaments for the treatment and/or prophylaxis of CB1 receptor related diseases in juvenile patients and/or for the treatment and/or prophylaxis of drug induced obesity in juvenile as well as in adolescent patients. The compounds have the general formula (1), wherein the group Bb represents sulfonyl or carbonyl, and the substituents R, R1, R2and R3, and the group Aa are defined as shown in the description.

La présente invention se rapporte à une nouvelle utilisation médicale de composés de 4,5-dihydro-1H-pyrazole, qui sont des antagonistes efficaces du récepteur au cannabis CB¿1?. Lesdits composés conviennent particulièrement à la fabrication de médicaments destinés au traitement et/ou à la prévention de maladies liées au récepteur CB¿1? chez des patients jeunes, et/ou au traitement et/ou à la prévention de l'obésité médicamenteuse chez des patients jeunes et adolescents. Les composés selon l'invention sont représentés par la formule générale (I), dans laquelle le groupe Bb représente sulfonyle ou carbonyle, et les substituants R, R¿1?, R¿2? et R¿3?, ainsi que le groupe Aa, sont tels que définis dans le descriptif de l'invention.

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