Use of 5-phenyl-2-furan ketones as antiepileptic agents

Details Use of 5-phenyl-2-furan ketones as antiepileptic agents Use of 5-phenyl-2-furan ketones as antiepileptic agents

C - Chemistry, Metallurgy

07

D

167/208, 167/245

C07D 307/38 (2006.01) A61K 31/395 (2006.01) C07D 307/52 (2006.01) C07D 307/54 (2006.01) C07D 307/68 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2018980

THE USE OF 5-PHENYL-2-FURAN KETONES AS ANTIEPILEPTIC AGENTS ABSTRACT OF THE DISCLOSURE A method of preventing epileptic seizures in a human or lower animal subject susceptible to said seizures, comprising systemically administering to said subject a safe and effective amount of a compound of the formu1a: Image wherein (a) X is halo or nil, and Y is a substituent selected from the group consisting of unsubstituted or halogen-substituted methyl, halo, nitro, amino, and methoxy; and (b) R is R1C(O)OH, R1C(O)N(R2)2, or R1N(R2)2; where R1 is C1-C3 alkyl which is unsubstituted or substituted with C1-C2 alkyl; and each R2 is, independently, hydrogen or lower alkyl; or both R2 groups are connected to form a saturated 5- or 6-membered heterocycle containing 1 or 2 heteroatoms selected from oxygen and nitrogen and said heterocycle is unsubstituted or substituted with lower alkyl or hydroxy-substituted lower alkyl; or a pharmaceutically-acceptable salt thereof. Preferably X is halo.

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