C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61P 25/18 (2006.01) C07J 1/00 (2006.01) C12N 9/02 (2006.01) C12P 33/06 (2006.01) C12Q 1/26 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2250874
Use is provided for a 7.alpha.-hydroxy or 7-oxo substituted 3.beta.-hydroxy- steroid possessing the carbon skeleton of cholesterol, androsterone, pregnenolone or estradiol, or an analogue thereof substituted independently at one or both of the 7- and 3-positions with an ester or ether group, in the manufacture of a pharmaceutical composition for the therapy of neuropsychiatric, immune and/or endocrine disorders or for inducing cognitive enhancement. Uses for Cyp7b enzymes in producing such steroids is also provided together with various novel steroids and test kits and methods for diagnosing the disorders.
L'invention concerne l'utilisation d'un 3.beta.-hydroxy-stéroïde à substitution 7.alpha.-hydroxy ou 7-oxo, possédant le squelette carboné du cholestérol, de l'androstérone, de la prégnénolone ou de l'oestradiol, ou un analogue de ceux-ci substitué indépendamment au niveau d'une ou des deux positions 7 et 3 par un groupe ester ou éther, pour la fabrication d'une composition pharmaceutique destinée au traitement de troubles neuropsychiatriques, immunitaires et/ou endocriniens, ou à l'induction d'une amélioration neuro-cognitive. L'invention concerne également l'utilisation d'enzymes cytochromes pour la production desdits stéroïdes, ainsi que de nouveaux stéroïdes, des trousses d'essais et des méthodes permettant de diagnostiquer les troubles en question.
Best Ruth
Lathe Richard
Leckie Caroline Mckenzie
Rose Kenneth Andrew
Seckl Jonathan Robert
Btg International Limited
Fetherstonhaugh & Co.
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