C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/30 (2006.01) A61K 31/522 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2387809
The present invention comprises a method of stimulating regeneration or survival of a mammalian motor neuron or of a mammalian sensory neuron comprising administering to a mammal an effective amount of a compound that is a 9-substituted hypoxanthine derivative linked through a linker to p- aminobenzoic acid moiety or of a salt or prodrug ester of such a compound. Preferably, the compound is N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide. The invention also includes pharmaceutical compositions formulated for stimulation of regeneration of a mammalian motor neuron comprising the 9-substituted hypoxanthine derivative and a pharmaceutically acceptable carrier.
La présente invention concerne une technique de stimulation de la régénération ou de la survie d'un motoneurone de mammifère ou d'un neurone sensoriel de mammifère, consistant à administrer à un mammifère une dose efficace d'un composé dérivé d'hypoxanthine 9-substituée, lié par un lieur à un groupe acide p-aminobenzoïque, ou d'un sel ou d'un ester de promédicament d'un tel composé. Ce composé est de préférence N-4-carboxyphényl-3-(6-oxohydropurin-9-yl) propanamide. L'invention concerne également des compositions pharmaceutiques formulées pour la stimulation de la régénération d'un motoneurone de mammifère comprenant le dérivé d'hypoxanthine 9-substituée et un excipient acceptable d'un point de vue pharmaceutique.
Glasky Alvin
Neotherapeutics Inc.
Smart & Biggar
LandOfFree
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