Use of a bis-peroxovanadium compound for the treatment of...

A - Human Necessities – 61 – K

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A61K 31/28 (2006.01) A61K 31/555 (2006.01) A61K 33/24 (2006.01) A61K 33/40 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2389348

The present invention provides a method for restoring the immune functions and the overall immune response by administration of a bis-peroxovanadium (bpV) compound, a potent class of phosphotyrosyl phosphatase inhibitors. The method can be utilized in treating individuals afflicted with immune disorders or for the treatment of patients suffering from infections caused by viruses that destroy the natural immune response, such as the human immunodeficiency virus (HIV). The bpV compound may be used in combination with various immunomodulators and/or antiviral agents. The present invention also relates to the use of such bpV compound for restoring the immune functions and the overall immune response in a patient in need of such a treatment.

L'invention concerne un procédé de restauration des fonctions immunes et de la réponse globale immune, ce procédé consistant à administrer un composé bis-peroxovanadium (bpV) faisant partie d'une famille de puissants inhibiteurs de la phosphotyrosylphosphatase. On peut utiliser ce procédé pour traiter des individus présentant des pathologies d'ordre immunitaire ou dans le traitement de patients soufrant d'infections provoquées par des virus détruisant la réponse immune naturelle, tels que le virus du syndrome immunodéficitaire acquis. Ce composé bpV peut s'utiliser en combinaison avec divers immunomodulateurs et/ou des agents antiviraux. L'invention concerne également l'utilisation d'un tel composé bpV, dans la restauration des fonctions immunes et de la réponse immune globale, chez un patient nécessitant un tel traitement.

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