Use of a calcium carbonate based porous material as support...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/19 (2006.01) A61K 31/194 (2006.01) A61K 31/66 (2006.01) A61K 33/06 (2006.01) A61K 33/10 (2006.01) A61K 33/42 (2006.01) A61K 35/00 (2006.01) A61K 38/18 (2006.01) A61L 27/00 (2006.01) A61L 27/02 (2006.01) A61L 27/12 (2006.01) A61L 27/22 (2006.01) A61L 27/36 (2006.01) A61L 27/38 (2006.01) A61L 27/58 (2006.01) C12N 5/00 (2006.01) C12N 11/14 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2139864

Use of a calcium carbonate based porous material as support for at least one growth factor in the preparation of a bioabsorbable implant to be placed in a living animal organism, in particular a vertebrate. In the case of an osteoinductive growth factor, the implant may be a bone filler or may be placed in a conjunctive tissue where it will generate bone tissue for use as an autograft. In the case of a non-osteoinductive growth factor, the implant may be used to grow cells in vivo. It is, for example, possible to use a hollow implant into which modified autologous cells are introduced, particularly by gene insertion. Once in place, the implant becomes an organoid correcting, for example, a dysfunction of genetic origin.

Utilisation d'un matériau poreux à base de carbonate de calcium comme support pour au moins un facteur de croissance dans la préparation d'un implant biorésorbable destiné à être mis en place dans un organisme animal vivant, en particulier chez un animal vertébré. Avec un facteur de croissance ostéoinducteur, l'implant peut constituer une pièce de comblement osseux, ou peut être implanté dans un tissu conjonctif où il donnera naissance à un tissu osseux utilisable comme autogreffe. Avec un facteur de croissance non ostéoinducteur, l'implant peut servir à cultiver des cellules in vivo. On peut par exemple utiliser un implant creux dans lequel on introduit des cellules autologues modifiées, notamment par insertion d'un gène. Après mise en place, l'implant constitue un organoïde permettant par exemple de remédier à un dysfonctionnement d'origine génétique.

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