Use of a cell membrane permeant calcium buffer for reducing...

Details Use of a cell membrane permeant calcium buffer for reducing... Use of a cell membrane permeant calcium buffer for reducing...

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 31/00 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/335 (2006.01) A61K 31/34 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2147123

A method of reducing the damaging effect of an injury to mammalian cells by treatment of the cell or mammalian tissue in vivo with a cell membrane permeant calcium buffer. The method comprises treating mammalian tissue with a damage reducing effective amount of the calcium buffer, preferably, a BAPTA derivative. The method may be used to control the concentration of Ca2+ ions in the vicinity of ion channel pores of the cells to prevent diffusion of toxic amounts of Ca2+ ions to subcellular sites located near the source of Ca2+ influx. The buffer treatment may be applied as a prophylactic or after the mammalian tissue has sustained injury. Pharmaceutical compositions comprising the calcium buffer and method of manufacture therefor are described.

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