C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/02 (2006.01) A61K 31/436 (2006.01) A61K 35/76 (2006.01) A61K 39/275 (2006.01) C12Q 1/04 (2006.01)
Patent
CA 2600675
The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.
L'invention concerne l'usage thérapeutique d'une combinaison associant le virus du myxome et la rapamycine. Le traitement par la rapamycine augmente la capacité du virus du myxome à infecter sélectivement les cellules qui présentent une réponse antivirale naturelle insuffisante, y compris les cellules insensibles à l'interféron. La combinaison de rapamycine et du virus du myxome peut servir à traiter les maladies caractérisées par la présence desdites cellules, notamment le cancer. Par ailleurs, l'invention concerne l'usage thérapeutique du virus du myxome qui n'exprime pas de M135R fonctionnel.
Barrett John
Mcfadden Grant
Stanford Marianne
Robarts Research Institute
Smart & Biggar
LandOfFree
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