Use of a cox-2 inhibitor for the treatment of a cox-2...

Details Use of a cox-2 inhibitor for the treatment of a cox-2... Use of a cox-2 inhibitor for the treatment of a cox-2...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2735677

This disclosure relates to a method of determining the presence of at least one HLA allele, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101 to assess whether a patient is at risk for developing hepatotoxicity upon administration of the COX-2 inhibitor lumiracoxib. Also disclosed is the use of a kit for carrying out this method. The disclosure also relates to a method of treating cyclooxygenase-2 dependent disorders with lumiracoxib in a subject that is not a carrier of one or more HLA alleles, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101.

La présente invention concerne une méthode de détermination de la présence d'au moins un allèle HLA, choisi de préférence dans le groupe constitué de DQA1*0102, DRB1*1501, DQB1*0602 et DRB5*0101, pour évaluer chez un patient le risque de développer une hépatotoxicité après administration de lumiracoxib, un inhibiteur de cox-2. L'invention concerne également l'utilisation d'une trousse permettant la mise en uvre de cette méthode. L'invention concerne en outre une méthode de traitement des troubles dépendant de la cyclooxygénase-2 avec le lumiracoxib chez un sujet qui n'est pas porteur d'un ou plusieurs allèles HLA, choisis de préférence dans le groupe constitué de DQA1*0102, DRB1*1501, DQB1*0602 et DRB5*0101.

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