Use of a cyclohexenone derivatives in the manufacture of a...

Details Use of a cyclohexenone derivatives in the manufacture of a... Use of a cyclohexenone derivatives in the manufacture of a...

A - Human Necessities

61

K

A61K 31/122 (2006.01) A61K 31/12 (2006.01) A61P 3/10 (2006.01) A61P 13/12 (2006.01) A61P 25/02 (2006.01) A61P 27/02 (2006.01) C07C 45/51 (2006.01) C07C 45/59 (2006.01) C07C 45/67 (2006.01) C07C 49/713 (2006.01)

Patent

CA 2438506

A preventive and/or therapeutic agent for diabetes complications, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group. The cyclohexenone long-chain alcoholic derivative of the present invention significantly suppresses a reduction in a peripheral nerve conduction rate and alleviates the hypofunction of the bladder so that it is useful as a preventive and/or therapeutic agent for diabetes complications, particularly, for diabetic neuropathy.

L'invention concerne un agent préventif et/ou thérapeutique destiné au traitement des complications diabétiques, comprenant comme ingrédient efficace un dérivé alcoolique à longue chaîne cyclohexenone représenté par la formule générale (1), dans laquelle R1, R2 et R3 représentent indépendamment un atome hydrogène ou un groupe méthyle et X représente un groupe alkylène ou alcénylène C10-28 linéaire ou ramifié. Ce dérivé alcoolique à longue chaîne cyclohexenone permet de protéger sensiblement le nerf périphérique contre toute diminution de conduction et de soulager une hypofonction de la vessie. Ce dérivé est par conséquent utile comme agent préventif et/ou thérapeutique dans le traitement des complications diabétiques, et, plus particulièrement, de la neuropathie diabétique.

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