Use of a cyclohexenone long-chain alcohol for treating...

A - Human Necessities – 61 – K

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A61K 31/122 (2006.01) A61P 25/28 (2006.01) C07C 49/743 (2006.01)

Patent

CA 2360246

A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R1, R2, and R3 represents a hydrogen atom or a methyl group; and X represents a C10-C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.

Ce médicament pour la prévention et le traitement de maladies neuro-dégénératives contient, comme ingrédient actif, un composé alcool à chaîne longue de cyclohexénone correspondant à la formule (1), formule dans laquelle R<1>, R<2> et R<3>, représentent un atome d'hydrogène ou un groupe méthyle, X représentant un groupe alkylène porteur de 10 à 28 atomes de carbone ou un groupe alkénylène. Dans la mesure où ce composé témoigne d'une remarquable capacité d'allongement des neurites ainsi que d'une action inhibitrice de troubles causés par une mutation dans le gène SOD, il se révèle des plus utile en tant qu'ingrédient actif d'un médicament de prévention et de traitement de maladies neuro-dégénératives, au nombre desquelles, entre autres, la sclérose latérale amyotrophique ainsi qu'en tant que médicament inhibiteur de troubles causés par une mutation dans le gène SOD.

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