Use of a cyclopentenone prostaglandin for delaying the onset...

A - Human Necessities – 61 – K

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A61K 31/5575 (2006.01) A61P 15/06 (2006.01)

Patent

CA 2589528

The present invention provides the use of a cyclopentenone prostaglandin in the manufacture of a medicament for delaying the onset and/or preventing the continuation of labour in a female. Preferably the cyclopentenone prostaglandin prevents and/or reduces an inflammatory response in the reproductive system of a female. Preferably, the cyclopentenone prostaglandin is 15-deoxy-.DELTA.12,14-prostaglandin J2, or prostaglandin A1 or a precursor thereof. The invention further provides a pharmaceutical composition comprising cyclopentenone prostaglandin and methods of use thereof.

La présente invention porte sur l'utilisation d'une cyclopenténone prostaglandine pour fabriquer un médicament visant à retarder le début et/ou empêcher la poursuite du travail chez une femme. La cyclopenténone prostaglandine de préférence prévient et/ou réduit une réponse inflammatoire dans l'appareil génital d'une femme. La cyclopenténone prostaglandine est de préférence une 15-désoxy-.DELTA.?12,14¿-prostaglandine J¿2 ?ou prostaglandine A¿1? ou un précurseur de celles-ci. Cette invention concerne également une composition pharmaceutique comprenant une cyclopenténone prostaglandine et des méthodes d'utilisation correspondantes.

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