Use of a cytokine from the interleukin-6 family in the...

A - Human Necessities – 61 – K

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Details

A61K 38/20 (2006.01) A61K 38/21 (2006.01) C07K 14/54 (2006.01) C07K 14/56 (2006.01)

Patent

CA 2612282

The invention relates to the use of at least one cytokine from the IL-6 family- gp130, preferably selected from among IL-11, the leukaemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1, ciliary neurotrophic factor (CNTF), the cardiotrophin-like cytokine (CLC) and combinations thereof or a DNA sequence encoding same, in the preparation of a pharmaceutical composition which is intended for combined administration with at least one interferon- alpha or a DNA sequence encoding same, for use in the treatment of viral diseases. The invention also relates to a pharmaceutical composition comprising a pharmaceutically-acceptable quantity of at least one cytokin from the IL-6 family-gp130 or a DNA sequence encoding same and a pharmaceutically- acceptable quantity of at least one interferon-alpha or a DNA sequence encoding same, a pharmaceutical kit and a method for the treatment of viral diseases with the combined administration of the aforementioned cytokines and interferon-alpha.

L'invention concerne l'utilisation d'au moins une cytokine de la famille IL-6 (famille gp130), de préférence sélectionnée parmi l'IL-11, le facteur inhibiteur de la leucémie (LIF), l'oncostatine M (OSM), la cardiotrophine-1, le facteur neurotrophique ciliaire (CNTF), la cytokine semblable à la cardiotrophine (CLC), et des combinaisons associées, ou une séquence ADN codant pour celle-ci, dans la préparation d'une composition pharmaceutique pour l'administation combinée avec au moins un interféron-alpha ou une séquence ADN codant pour celui-ci, dans le traitement de maladies virales. L'invention concerne également une composition pharmaceutique qui comprend une dose acceptable sur le plan pharmaceutique d'au moins une cytokine de la famille IL-6 (famille gp130), ou une séquence ADN codant pour celle-ci, et une dose acceptable sur le plan pharmaceutique d'au moins un interféron-alpha, ou une séquence ADN codant pour celui-ci. L'invention concerne également un kit pharmaceutique et une méthode de traitement de maladies virales par administration combinée des cytokines mentionnées et de l'interféron-alpha.

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