Use of a cytokine-producing lactococcus strain to treat colitis

Details Use of a cytokine-producing lactococcus strain to treat colitis Use of a cytokine-producing lactococcus strain to treat colitis

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 35/74 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) C07K 14/52 (2006.01) C07K 14/715 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2343840

The current invention relates to an administraton strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, such as IL10 and/or soluble TNF receptor via the oral route. The prefered feature according to the invention is the inoculation with a suspension of recombinant Lactococcus lactis cells, which had been engineered to produce the respective proteins.

Cette invention a trait à une stratégie thérapeutique d'administration, au niveau de la muqueuse intestinale, de cytokines ou d'antagonistes de cytokine, de préférence, des agents anti-inflammatoires réagissant aux acides, notamment l'interleukine-10 et/ou un récepteur soluble du TNF et ce, par voie orale. Le mode opératoire préféré, dans le cadre de cette invention, est l'inoculation d'une suspension de cellules de Lactococcus lactis de recombinaison ayant été modifiées par génie génétique afin de leur faire produire les protéines respectives.

Affiliated with

Also associated with

Rating

Use of a cytokine-producing lactococcus strain to treat colitis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of a cytokine-producing lactococcus strain to treat colitis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of a cytokine-producing lactococcus strain to treat colitis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1964626