Use of a drug capable of modulating the regulation of upc-2...

A - Human Necessities – 61 – K

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Details

A61K 31/195 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2295747

The invention relates to a method for treatment of obesity, metabolic syndrome and/or non-insulin dependent diabetes mellitus by administering a drug capable of modulating the regulation of UCP-2, the use of a drug capable of modulating the regulation of UCP-2 for the production of drug for treatment of obesity, metabolic syndrome and/or non-insulin dependent diabetes mellitus and pharmaceutical composition comprising a pharmaceutically effective amount of such a drug. The invention is also related to methods for screening for potential drugs against obesity, metabolic syndrome and/or non-insulin dependent diabetes mellitus and the use of cDNA probe for determination of upregulation of UCP-2 for potential drugs against obesity, metabolic syndrome and/or non-insulin dependent diabetes mellitus.

Cette invention concerne un procédé permettant de traiter l'obésité, les syndromes métaboliques et/ou les diabètes ne dépendant pas de l'insuline, lequel procédé consiste à administrer un médicament capable de moduler la régulation de l'UCP-2. Cette invention concerne également l'utilisation d'un médicament permettant de moduler la régulation de l'UCP-2 en vue de la production d'un médicament permettant de traiter l'obésité, les syndromes métaboliques et/ou les diabètes ne dépendant pas de l'insuline. Cette invention concerne aussi une composition pharmaceutique qui comprend une quantité suffisante pour être efficace de ce médicament. L'invention concerne en outre des procédés qui permettent de trier des médicaments potentiels permettant de lutter contre l'obésité, les syndromes métaboliques et/ou les diabètes ne dépendant pas de l'insuline. Cette invention concerne enfin l'utilisation d'une sonde d'ADNc qui permet de déterminer la régulation à la hausse de l'UCP-2 afin d'obtenir des médicaments potentiels contre l'obésité, les syndromes métaboliques et/ou les diabètes ne dépendant pas de l'insuline.

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