Use of a hydrophilic matrix comprising a polyacrylic acid...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 31/496 (2006.01) A61P 15/02 (2006.01)

Patent

CA 2652226

A hydrophilic matrix is disclosed which comprises: a) at least one polyacrylic acid derivative in preferred amounts of 0.5 - 40%, b) at least one cellulose ether in preferred amounts of 30 - 90% and c) at least one disintegrant in preferred amounts of 2 - 50%, with respect to the weight of the matrix. This matrix is used in combination with at least one pharmaceutically acceptable active principle for manufacturing solid bioadhesive controlled release formulations for the treatment of vaginal disorders, such as vulvovaginal candidiasis, bacterial vaginosis or trichomoniasis. The matrix is used in solid formulations in amounts of about 5 - 60%, preferably 20-40%, and the active principle in amounts of about 2- 70 %, preferably 5-50% with respect to the weight of the formulation.

L'invention concerne la description d'une matrice hydrophile qui comporte : a) au moins un dérivé de l'acide polyacrylique en quantités préférées de 0,5 à 40 %, b) au moins un éther de cellulose en quantités préférées de 30 à 90 % et c) au moins un délitant en quantités préférées de 2 à 50 %, par rapport au poids de la matrice. Cette matrice est utilisée conjointement avec au moins un principe actif acceptable pharmaceutiquement afin de fabriquer des formulations solides à libération contrôlée bioadhésives pour traiter des troubles vaginaux, tels qu'une candidose vulvovaginale, une vaginose bactérienne ou une trichomonase. La matrice est utilisée dans des formulations solides en quantités de 5 à 60 % environ, de préférence de 20 à 40 %, et le principe actif en quantités de 2 à 70 % environ, de préférence de 5 à 50 % par rapport au poids de la formulation.

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