A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C07K 14/42 (2006.01) C07K 19/00 (2006.01) C12N 15/29 (2006.01)
Patent
CA 2368641
The present invention relates to the treatment of pain and to compounds that modulate C-fibre activity. In particular, the present invention relates to the use of a lectin in the manufacture of a medicament for modulation of C-fibre neurone activity, and to lectin conjugates. The lectin conjugates comprise a lectin coupled to a peptide or protein, wherein the peptide or protein is substantially free of Clostridial neurotoxin enzyme activity. The present invention also concerns methods for manufacturing said conjugates. The compounds and compositions described have particular application in the treatment of diseases of which C-fibre activity is a component. Such diseases include pain, inflammation, psoriasis and other C-fibre related conditions.
L'invention concerne le traitement de la douleur, ainsi que des composés agissant sur l'activité de la fibre C. L'invention concerne en particulier l'utilisation d'une lectine dans la préparation d'un médicament destiné à moduler l'activité de la fibre C, et concerne également des conjugués de la lectine. Ces derniers renferment une lectine couplée à un peptide ou à une protéine, la protéine ou le peptide étant sensiblement exempt d'activité enzymatique de la neurotoxine clostridiale. La présente invention concerne en outre des procédés de préparation desdits conjugués. Les composés et les compositions décrites trouvent une application particulière dans le traitement de maladies, telles que, par exemple, la douleur, les inflammations, le psoriasis, dont la fibre C est une composante.
Chaddock John Andrew
Foster Keith Alan
Quinn Conrad Padraig
Goudreau Gage Dubuc
Microbiological Research Authority
Syntaxin Limited
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