A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61P 31/00 (2006.01)
Patent
CA 2480196
Disclosed is the use of lipopeptides and lipoproteins as mucosal adjuvants for various vaccinations via mucous membranes, particularly intranasally. Said lipopeptides represent peptides or proteins substituted with 2,3-diacyloxy(2R)- propyl at the amino-terminal cystein of a peptide or protein, preferably S- (2,3-bispalmitoyloxy-(2R)-propyl)cysteinyl peptides derived from mycoplasmas. Said peptides are highly effective even in small doses, produce good immunization results, and increase the IgA level, among others.
L'invention concerne des lipopeptides et lipoprotéines utilisés comme adjuvants mucosaux destinés à diverses vaccinations par les muqueuses, notamment par les voies intranasales. Les lipopeptides sont des peptides ou protéines substitués par un 2,3-diacyloxy(2<i>R</i>)-propyle au niveau de la cystéine aminoterminale d'un peptide ou d'une protéine, de préférence, des S-(2,3-bispalmitoyloxy-(2<i>R</i>)-propyle)-cystéinyle-peptides dérivés de mycoplasmes. Les peptides susmentionnés sont hautement efficaces à faible dose et donnent de bons résultats d'immunisation et une augmentation notamment du niveau de IgA.
Guzman Carlos Alberto
Muhlradt Peter
Gbf Gesellschaft Fuer Biotechnologische Forschung Mbh
Helmholtz-Zentrum Fuer Infektionsforschung Gmbh
Kirby Eades Gale Baker
LandOfFree
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