A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/21 (2006.01) A61K 38/22 (2006.01) A61K 38/39 (2006.01) A61K 47/08 (2006.01) A61K 47/22 (2006.01)
Patent
CA 2340549
The invention provides methods of protecting solid-state proteins from the effects of ionizing radiation which comprise combining the protein with a radiation- protecting amount of a methoxysalicylaldehyde derivative, preferably 3- methoxysalicylaldehyde; radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid; or radiation-protecting amounts of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol, prior to exposing the protein to ionizing radiation. The invention further provides radiation-resistant pharmaceutical formulations comprising a protein and a methoxysalicylaldehyde derivative, preferably 3- methoxysalicylaldehyde; a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid; or a protein and a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde and isopropanol. The invention still further provides a composition comprising a combination of a methoxysalicylaldehyde derivative, preferably 3-methoxysalicylaldehyde, and 6- hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, and for the use of such composition in pharmaceutical formulations as a radioprotectant.
Kimball Roger Nelson
Reddy Renuka Devi
Shalaev Evgenyi Yur'evich
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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