A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7105 (2006.01) A61P 9/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2341638
The present invention provides a pharmaceutical composition for the prevention or treatment of angiostenosis, comprising a compound inhibiting the function of midkine (MK) in blood vessel tissues as an effective ingredient. The present invention is useful for the prevention or treatment of angiostenosis attributed to arteriosclerosis or restenosis after percutaneous transluminal coronary angioplasty (PTCA). As compounds inhibiting the function of MK, antisense oligonucleotides that bind to a segment of a single-stranded mRNA transcribed from the MK gene to inhibit the synthesis of MK protein in cells, antibodies against the MK protein, and such can be used.
La présente invention concerne des compositions médicinales de prévention ou de traitement de l'angiosténose dont les principes actifs sont des composés bloquant la fonction MK dans les tissus vasculaires. Ces compositions conviennent à la prévention et au traitement de la réangiosténose consécutive à une angioplastie coronarienne transluminale percutanée (ACTP) ou l'angiosténose provoquée par l'artériosclérose. Comme composés bloquant la fonction MK, on peut employer, d'une part un oligonucléotide antisens se liant au segment d'ARN messager monobrin transcrit à partir du gène MK et qui vient par conséquent bloquer la synthèse de la protéine MK dans les cellules, et d'autre part un anticorps dirigé contre la protéine MK.
Horiba Mitsuru
Ikematsu Shinya
Kadomatsu Kenji
Muramatsu Takashi
Sakuma Sadatoshi
Medical Therapies Limited
Meiji Milk Products Co. Ltd.
Muramatsu Takashi
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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