A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/285 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 39/29 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2593532
The present invention relates to the rapid induction of a protective immune response against poxviruses and poxvirus infections such as smallpox by vaccination of an animal, including a human with a poxvirus that is replication incompetent in said animal including the human. An example for such a poxvirus is a Modified Vaccinia virus Ankara (MVA). The invention further relates to the use of a recombinant poxvirus that is replication incompetent in the animal, including the human that is vaccinated with the virus, such as a recombinant MVA expressing heterologous antigens and/or antigenic epitopes for a rapid induction of an protective immune responses against said heterologous antigen and/or antigenic epitope, e.g. against an antigen and/or antigenic epitope that is part of an infectious agent.
La présente invention concerne l~induction rapide d~une réponse immunitaire de protection contre les virus de la variole et des infections par les virus de la variole comme la varicelle par vaccination d~un animal, y compris un humain avec un virus de la variole dont la réplication est incompétente chez ledit animal, y compris l~être humain. Un exemple de tel virus de la variole est un Vaccinia virus Ankara Modifié (MVA). L~invention concerne de plus l~utilisation d~un virus de la variole de recombinaison dont la réplication est incompétente chez l~animal, y compris l~être humain qui est vacciné avec le virus, comme des antigènes et/ou des épitopes antigéniques hétérologues exprimant le MVA de recombinaison pour une induction rapide de réponses immunitaires de protection contre ledit antigène et/ou épitope antigénique hétérologue, par exemple contre un antigène et/ou un épitope antigénique qui est partie intégrante d~un agent infectieux.
Chaplin Paul
Mateo Luis
Bavarian Nordic A/s
Smart & Biggar
LandOfFree
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