Use of a modified rev-responsive element (rre) in methods...

Details Use of a modified rev-responsive element (rre) in methods... Use of a modified rev-responsive element (rre) in methods...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/16 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2252225

The invention relates to an isolated nucleic acid comprising two operatively linked binding sites for HIV Rev protein, the sites comprising a nucleation motif and an oligomerization motif, wherein the nucleic acid binds Rev protein monomers with a higher degree of co-operativity than wild-type RRE.

L'invention concerne un acide nucléique isolé qui comprend deux sites de liaison liés de manière opérationnelle et destinés à la protéine Rev du VIH. Ces sites comprennent un motif de nucléation et un motif d'oligomérisation. L'acide nucléique lie des monomères de ladite protéine Rev avec davantage de coopérativité qu'un RRE de type sauvage.

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