A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2664145
The present invention is concerned with the finding that some the macrocyclic quinazoline derivative 4,6-ethanediylidenepyrimido[4,5-b][6,1,12]benzoxadiazacyclo-pentadecine, 17-bromo-8,9,10,11,12,13,14,19-octahydro-20-methoxy-13-methyl-, described as compound 22 in PCT publication WO2004/105765, is useful in the manufacture of a medicament for the treatment or prevention of a primary brain cancer or brain metastasis. It accordingly provides methods for treating, preventing, delaying or mitigating brain cancer, or for preventing or slowing proliferation of cells of brain origin.
La présente invention concerne la découverte qu'un certain dérivé macrocyclique de la quinazoline, la 17-bromo-8,9,10,11,12,13,14,19-octahydro-20-méthoxy-13-méthyl-4,6-éthanediylidènepyrimido[4,5-b][6,1,12]benzoxadiazacyclopentadécine, décrit comme étant le composé 22 dans la publication PCT WO2004/105765, est utile dans la fabrication d'un médicament pour le traitement ou la prévention d'un cancer du cerveau primaire ou d'une métastase au cerveau. L'invention concerne par conséquent des procédés servant à traiter, prévenir, retarder ou atténuer un cancer du cerveau ou à prévenir ou ralentir la prolifération de cellules d'origine cérébrale.
Freyne Eddy Jean Edgard
Janicot Michel Marie Francois
Page Martin John
Perera Timothy Pietro Suren
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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