Use of a nitric oxide donor to prevent desensitization of...

Details Use of a nitric oxide donor to prevent desensitization of... Use of a nitric oxide donor to prevent desensitization of...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/14 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2503624

Desensitization of receptors that control disease is prevented by inhibiting G- protein receptor kinases. This has applicability, e.g., for patients with heart failure or on a left ventricular heart device or a heart pump after surgery or about to undergo surgery and at high risk for a cardiac event or on an opiate or addicted to opiate or with cystic fibrosis or rheumatoid arthritis.

L'invention concerne la prévention de la désensibilisation de récepteurs qui commandent des maladies par inhibition des kinases des récepteurs de la protéine G. Ce traitement s'applique par exemple à des patients souffrant d'insuffisance cardiaques ou étant dotés d'un dispositif cardiaque ventriculaire gauche ou d'une pompe cardiaque, ayant subi ou sur le point de subir une intervention et présentant un grand risque d'événement cardiaque. Le traitement convient également pou un opiacé ou toxicomane ou un patient présentant une fibrose cystique ou de l'arthrite rhumatoïde.

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