Use of a nonimmunosuppressive cyclosporin a derivative for...

A - Human Necessities – 61 – K

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A61K 8/64 (2006.01) A61Q 5/00 (2006.01) A61Q 5/02 (2006.01) A61Q 7/00 (2006.01)

Patent

CA 2380362

The present invention relates to agents for treating alopecia and stimulating hair growth comprising an active ingredient of nonimmunosuppresive [.gamma. - hydroxy-N-methyl-L-leucine4] cyclosporin A having superior hair growth-promoting effect, wherein the hydroxyl group is added to the .gamma. carbon position of No.4 N- methyl-L-leucine of cyclosporin A by the microorganism.

La présente invention concerne des agents destinés au traitement de l'alopécie permettant de stimuler la croissance des cheveux. Ces agents comprennent un ingrédient actif de [ gamma -hydroxy-N-méthyl-L-leucine<4>] cyclosporine A non immunosuppressive stimulant efficacement la croissance des cheveux, le groupe hydroxy étant ajouté à la position du carbone gamma de la N-méthyl-L-leucine n DEG 4 de la cyclosporine A par un micro-organisme.

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