C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 47/48 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07K 14/705 (2006.01) C12N 5/00 (2006.01) C12Q 1/02 (2006.01) C07K 16/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2271248
The present invention relates to the use of therapeutic compounds in the modification of T-cell, T-cell-antigen presenting cell (APC) interactions and the interactions between pathogenic organisms and immunocompetent cells of a host. In particular it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligands and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, and asthma and infectious diseases.
La présente invention porte sur l'utilisation de composés thérapeutiques dans la modification des interactions entre des lymphocytes T, et entre des cellules présentatrices de l'antigène et des lymphocytes T, et des interactions entre des organismes pathogènes et des cellules immunocompétentes d'un hôte. L'invention porte en particulier sur l'utilisation desdits composés, d'une part, dans la modulation de l'interaction entre des protéine notch et leurs ligands, et, d'autre part, dans le traitement de pathologies telles que le rejet de greffe, l'auto-immunité, l'allergie, l'asthme et des maladies infectieuses.
Dallman Margaret Jane
Hoyne Gerald Francis
Lamb Jonathan Robert
Celldex Therapeutics Limited
Gowling Lafleur Henderson Llp
Lorantis Limited
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