C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2423703
The invention concerns the use of a nucleic acid/cationic polymer complex, preferably polyethyleneimine (PEI) for preparing a composition for intraventricular stereotactic screening of stem cells of the brain for preparing a medicine for treating neurodegenerative and/or demyelinating diseases. The invention further concerns a method for obtaining an animal whereof the genome of stem cells of the brain are modified by using said complex. The invention also concerns a method for obtaining an animal for screening compounds designed to modify the disposition of stem cells of the brain.
L'invention concerne l'utilisation d'un complexe acide nucléique/polymère cationique, de préférence le polyéthylènéimine (PEI) pour la préparation d'une composition destinée au ciblage par voie stéréotaxique intraventiculaire de cellules souches du cerveau pour la preéparation d'un médicament destiné au tratiement des maladies neurodégénératives et/ou démyélinisantes. L'invention concrene en outre un procédé d'obtention d'un animal dont le génome des cellules souches du cerveau sont modifiés par l'utilisation dudit complexe. L'invention concerne également un procédé d'obtention d'un animal destiné au criblage de composés destinés à modifier le devenir des cellules souches du cerveau.
Demeneix Barbara
Lemkine Gregory
Levi Giovanni
Centre National de La Recherche Scientifique
Museum National D'histoire Naturelle
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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