Use of a polypeptide as cell receptor for adenoviruses

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/075 (2006.01) C07K 14/74 (2006.01) C07K 14/78 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2251036

The invention concerns the use of a polypeptide comprising at least 6 continuous amino acids of the sequence as shown in the sequence identifiers 1 to 5 as cell receptor and/or co-receptor of adenoviruses. It also concerns the use of a cell capable of expressing such a polypeptide and that of a ligand capable of influencing the binding of an adenovirus to a host cell and/or its insertion in said cell. Finally, the invention further concerns a method for selecting or identifying a cell receptor of a virus or part of a viral protein determining the binding of the virus to its cell receptor and the use of a bi-functional ligand for targeting an adenovirus towards a host cell bearing on its surface a surface protein other than the natural cell receptor of said adenovirus.

La présente invention a pour objet l'utilisation d'un polypeptide comprenant au moins 6 acides aminés continus de la séquence telle que montrée dans les identificateurs de séquence 1 à 5 à titre de récepteur et/ou co-récepteur cellulaire des adénovirus. Elle concerne également l'utilisation d'une cellule capable d'exprimer un tel polypeptide ainsi que celle d'un ligand capable d'influencer l'attachement d'un adénovirus à une cellule hôte et/ou son entrée au sein de ladite cellule hôte. Enfin, elle a également trait à une méthode pour sélectionner ou identifier un récepteur cellulaire d'un virus ou la partie d'une protéine virale déterminant l'attachement du virus à son récepteur cellulaire ainsi qu'à l'utilisation d'un ligand bifonctionnel pour cibler un adénovirus vers une cellule hôte portant à sa surface une protéine de surface autre que le récepteur cellulaire naturel dudit adénovirus.

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