G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 25/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2379336
The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide sequence in native state corresponds to SEQ ID No 1, SEQ ID No 2, SEQ ID No 3, SEQ ID No 4, SEQ ID No 5, SEQ ID No 6, SEQ ID No 7, SEQ ID No 8, SEQ ID No 9, SEQ ID No 10, SEQ ID No 11, SEQ ID No 12, SEQ ID No 13, SEQ ID No 14, SEQ ID No 15, SEQ ID No 16, SEQ ID No 17, SEQ ID No 18, SEQ ID No 19, SEQ ID No 20, SEQ ID No 21, SEQ ID No 22, SEQ ID No 23, SEQ ID No 24, SEQ ID No 25, SEQ ID No 26, SEQ ID No 27, SEQ ID No 28 and SEQ ID No 29, and the peptide sequences having at least 70 % identity, preferably at least 80 % identity and advantageously at least 98 % identity with any one of the peptide sequences SEQ ID No 1 to SEQ ID No 8 and SEQ ID No 10 to SEQ ID No 29, and the peptide sequences or fragments of said sequences belonging to a common family of proteins selected among perlecan, the precursor of the retinol-binding plasmatic protein, of the precursor of the activator of GM2 ganglioside, of calgranulin B and of saposin B.
Utilisation d'au moins un polypeptide comprenant au moins un fragment d'une protéine pour obtenir une composition diagnostique, pronostique, prophylactique ou thérapeutique destinée à détecter, prévenir ou traiter un état pathologique associé à une maladie dégénérative et/ou neurologique et/ou auto-immune, ladite protéine étant choisie parmi les protéines dont la séquence peptidique à l'état natif correspond à SEQ ID N~ 1, SEQ ID N~ 2, SEQ ID N~ 3, SEQ ID N~ 4, SEQ ID N~ 5, SEQ ID N~ 6, SEQ ID N~ 7, SEQ ID N~ 8, SEQ ID N~ 10, SEQ ID N~ 11, SEQ ID N~ 12, SEQ ID N~ 13, SEQ ID N~ 14, SEQ ID N~ 15, SEQ ID N~ 16, SEQ ID N~ 17, SEQ ID N~ 18, SEQ ID N~ 19, SEQ ID N~ 20, SEQ ID N~ 21, SEQ ID N~ 22, SEQ ID N~ 23, SEQ ID N~ 24, SEQ ID N~ 25, SEQ ID N~ 26, SEQ ID N~ 27, SEQ ID N~ 28 et SEQ ID N~ 29, et les séquences peptidiques qui présentent au moins 70 % d'identité, de préférence au moins 80 % d'identité et avantageusement au moins 98 % d'identité avec l'une quelconque des séquences peptidiques SEQ ID N~ 1 à SEQ ID N~ 8 et SEQ ID N~ 10 à SEQ ID N~ 29, et les séquences peptidiques ou les fragments desdites séquences appartenant à une même famille de protéines choisies parmi le perlecan, le précurseur de la protéine plasmatique de liaison au rétinol, du précurseur de l'activateur du ganglioside GM2, de la calgranuline B et de la saposine B.
Charles Marie-Helene
Kolbe Hanno
Malcus Carine
Perron Herve
Roecklin Dominique
Biomerieux Stelhys
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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