Use of a prostaglandin derivative as an anti-pruritic agent

Details Use of a prostaglandin derivative as an anti-pruritic agent Use of a prostaglandin derivative as an anti-pruritic agent

A - Human Necessities

61

K

A61K 31/5575 (2006.01) A61P 17/00 (2006.01) A61P 17/04 (2006.01) A61P 27/02 (2006.01) C07C 405/00 (2006.01)

Patent

CA 2465103

A pharmaceutical preparation for preventing or treating pruritic symptoms which contains as an effective ingredient a prostaglandin derivative represented by formula [1] (see formula 1) wherein X1 and X2 which are different from each other represent a hydrogen atom, a halogen atom or a hydroxyl group; Y is an ethylene group, a vinylene group or an ethynylene group; Z is the formula (CH2)k A(CH2)h B(CH2)q, (CH2)k A(CH2)r A'(CH2)t, (CH2)k B(CH2)h B'(CH2)q or (CH2)k-1B'(CH2)q-1A' wherein k is an integer of 1 to 4, h is an integer of 0 to 4, q is an integer 1 to 4, r is an integer of 0 to 4, and t is an integer of 0 to 2; A and A' which may be the same or different represent an ethylene group, a vinylene group or an ethynylene group; B and B' which may be the same or different represent an oxygen atom or a group represented by the formula S(O), wherein u is an integer of 0 to 2; W1 is a hydroxyl group, a C1-10 alkyloxy group, a C3-10 cycloalkyloxy group, an aryloxy group or an arylalkyloxy group; W2 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, a C3-10 cycloalkyl group, a C1-5 alkyl group substituted by C3-10 cycloalkyl group(s), or a group represented by the formula (see above formula) wherein W4 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group or a C1-5 alkyl group substituted by C3-10 cycloalkyl group(s); v is an integer of 0 to 4; W3 is a hydrogen atom or a methyl group, or W3 when taken together with W2 and the adjacent carbon atom forms a C3-10 cycloalkyl group; m is 0 or 1, a pharmaceutically acceptable salt thereof or a hydrate thereof.

L'invention concerne un médicament destiné à la prévention ou au traitement des symptômes de démangeaison. Ce médicament contient, comme principe actif, un dérivé de la prostaglandine représenté par la formule (1), dans laquelle X?1¿ et X?2¿ sont différents et chacun représente hydrogène, halogéno ou hydroxy. L'invention concerne également un sel pharmaceutiquement acceptable du dérivé ou un hydrate du dérivé.

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