A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 31/7088 (2006.01) C07K 14/47 (2006.01) C12N 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2461692
The invention concerns the use of at least a protein of the CRMP family, a polypeptide fragment or an active biological derivative thereof, a nucleotide sequence or sequence fragment coding for said protein, an antisense sequence capable of being specifically hybridized with a sequence with nucleotide-type encoding of said protein or an antibody directed against said protein for producing a medicine for treating diseases related to a dysfunction of the immune system. The invention also concerns a method for diagnosing an autoimmune pathology which consists in measuring the expression of a CRMP protein in the lymphocytes.
La présente invention concerne l'utilisation d'au moins une protéine de la famille CRMPs, fragment polypeptidique ou dérivé biologiquement actif de celle- ci, d'une séquence ou fragment de séquence nucléotidique codant pour ladite protéine, d'une séquence anti-sens capable de s'hybrider spécifiquement avec une séquence nucléotidiquement codant pour ladite protéine ou un anticorps dirigé contre ladite protéine pour la fabrication d'un médicament destiné à traiter les maladies liées à un dysfonctionnement du système immunitaire.Elle vise également une méthode de diagnostic d'une pathologie auto-immune consistant à mesurer l'expression d'une protéine CRMP dans les lymphocytes.
Antoine Jean-Christophe
Belin Marie-Francoise
Colas Pierre
Giraudon Pascale
Honnorat Jerome
Institut National de La Sante Et de La Recherche Medicale (inser
Robic
LandOfFree
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