Use of a protein or nitrated peptide sequence for...

G - Physics – 01 – N

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G01N 33/68 (2006.01) C07K 1/113 (2006.01) C07K 16/16 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2711867

The invention relates to the use of a quantitative assay, particularly in vitro, in a biological sample, of the nitration ratio of the tyrosine residue of a protein or a nitrated predetermined physiological peptide sequence, in order to implement an in vitro diagnosis method of the severity of or risk of developing a chronic or acute disease linked with nitrating stress.

La présente invention a pour objet l'utilisation du dosage quantitatif, notamment in vitro, dans un échantillon biologique, du taux de nitration de résidus tyrosine d'une protéine ou d'une séquence peptidique physiologique déterminée nitrée, pour la mise en oeuvre d'une méthode de diagnostic in vitro de l'état de gravité et d'évolutivité d'une pathologie chronique ou aigüe associée au stress nitrant.

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