A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/427 (2006.01)
Patent
CA 2604799
A method for improving the pharmacokinetics of drugs, which are metabolized by cytochrome P450 monooxygenase is disclosed. More specifically it relates to a method for improving the pharmacokinetics of retroviral protease inhibitors and in particular for improving the pharmacokinetics of human immunodeficiency virus (HIV) protease inhibitors. A pharmaceutical composition and its use in the manufacture of a medicament for the inhibition or treatment of an HIV infection or AIDS in a human being are also part of the invention.
L'invention concerne un procédé permettant d'améliorer la pharmacocinétique de médicaments métabolisés par la cytochrome P450 monooxygénase. Plus précisément, l'invention concerne un procédé permettant d'améliorer la pharmacocinétique d'inhibiteurs des protéases rétrovirales et, plus précisément, permettant d'améliorer la pharmacocinétique d'inhibiteurs de la protéase du virus de l'immunodéficience humaine (VIH). L'invention concerne enfin une composition pharmaceutique et l'utilisation de celle-ci dans la fabrication d'un médicament destiné à l'inhibition ou au traitement d'une infection au VIH ou SIDA chez un être humain.
Baert Lieven Elvire Colette
de Kock Herman Augustinus
de Meyer Sandra
Van 't Klooster Gerben Albert Eleutherius
Wigerinck Piet Tom Bert Paul
Gowling Lafleur Henderson Llp
Tibotec Pharmaceuticals Ltd.
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