Use of a trioxopyrimidine for the treatment and prevention...

Details Use of a trioxopyrimidine for the treatment and prevention... Use of a trioxopyrimidine for the treatment and prevention...

A - Human Necessities

61

K

A61K 31/515 (2006.01) A61K 31/724 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2561828

The invention provides the use of a trioxopyrimidine compound having an inhibitory activity against MMP-1, MMP-2, MMP-3, MMP-9 and MMP-14 defined as a) an IC50 value of less than 5 ~M for MMP-2, MMP-9 and MMP-14 each; b) a ratio of more than 100 for the IC50 values of MMP-1:MMP-2, MMP-1: MMP-9, MMP- 1:MMP-14; and c) a ratio of more than 10 for the IC50 values of MMP-~3:MMP-2, MMP-3: MMP-9, MMP-3:MMP-14, for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases.

L'invention concerne l'utilisation d'un composé de trioxopyrimidine possédant une activité inhibitrice contre MMP-1, MMP-2, MMP-3, MMP-9 et MMP-14 définis comme a) une valeur IC¿50? inférieure à 5 ?M pour MMP-2, MMP-9 et MMP-14 individuellement; b) un rapport supérieur à 100 pour les valeurs IC¿50? de MMP-1:MMP-2, MMP-1: MMP-9, MMP-1:MMP-14; et c) un rapport supérieur à 10 pour les valeurs IC¿50? de MMP--3:MMP-2, MMP-3: MMP-9, MMP-3:MMP-14, aux fins de fabrication d'un médicament destiné au traitement ou à la prévention de maladies inflammatoires bronchiques.

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