Use of a trpm5 inhibitor to regulate insulin and glp-1 release

Details Use of a trpm5 inhibitor to regulate insulin and glp-1 release Use of a trpm5 inhibitor to regulate insulin and glp-1 release

A - Human Necessities

61

K

A61K 31/16 (2006.01) A61K 31/277 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/439 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61K 31/47 (2006.01) A61K 31/4706 (2006.01) A61K 31/5375 (2006.01) A61K 31/655 (2006.01)

Patent

CA 2677230

The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.

L'invention concerne des procédés d'amélioration d'une sécrétion d'insuline, d'une sécrétion de GLP-1, et d'une sensibilité à l'insuline, des procédés d'augmentation de l'expression du gène d'insuline, des procédés de diminution de sécrétion et de vidange gastrique, et de diminution de sécrétion de glucagons, des procédés d'inhibition de prise alimentaire, et des procédés de traitement du diabète sucré, du syndrome d'insuline-résistance, de l'hyperglycémie et de l'obésité, comprenant l'administration à un sujet d'une quantité efficace d'un inhibiteur de TRPM5.

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