Use of acetylcholinesterase inhibitors on the modulation of...

A - Human Necessities – 61 – K

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A61K 31/44 (2006.01) A61K 31/195 (2006.01) A61K 31/27 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 15/08 (2006.01)

Patent

CA 2354035

Acetylcholinesterase inhibitors are of use for treating a variety of conditions that can benefit from stimulation of the hypothalamic-pituitary- gonadal axis such as failure of ovulation, some cases of unexplained infertility, luteal phase defect, hypogonadotrophic hypogonadism, aesthenozoospermia, oligozoospermia, delayed onset of puberty and crytorchidism. Suitable acetylcholinesterase inhibitors include donepizil, rivastigmine galanthamine, lycoramine and analogs thereof.

On utilise des inhibiteurs d'acétylcholine estérase pour traiter divers états pathologiques pouvant bénéficier de la stimulation de l'axe hypothalamo-hypophyso-gonadique, notamment des défaillances de l'ovulation, certains cas de stérilité inexpliquée, une défaillance de la phase lutéinique, l'hypogonadisme hypogonadotrophique, l'asthénozoospermie, l'oligozoospermie, le retard de l'apparition de la puberté et le cryptorchidisme. Parmi ces inhibiteurs de l'acétylcholine estérase, on compte le donepizil, la galanthamine rivastigmine, la lycoramine et leurs analogues.

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