A - Human Necessities – 61 – N
Patent
A - Human Necessities
61
N
A61N 5/00 (2006.01) A61K 31/295 (2006.01) A61K 31/505 (2006.01) A61K 31/555 (2006.01) A61K 33/24 (2006.01)
Patent
CA 2213344
This invention relates to the use of organometallic compounds of transition metals in the treatment of cancer. The organometallic compounds of the invention generate active radical species in mildly acidic conditions characteristic tumors. The active radical species generated by said compounds are capable of cleaving and damaging biomolecules, including nucleic acids and cellular structures in tumors. Hence, the organometallic compounds of the invention can be used in the treatment of cancer. In addition, these compounds have increased anti-cancer efficacy when administered in conjunction with factors which intensify glycolysis, such as hyperglycemia and/or hyperthermia, or when used in conjunction with anti-cancer agents and/or radiotherapy.
On utilise des composés organométalliques de métaux de transition pour traiter des cancers. Ces composés organométalliques produisent, dans des conditions légèrement acides caractéristiques de tumeurs, des radicaux actifs pouvant couper et endommager des biomolécules, y compris des acides nucléiques et les structures cellulaires des tumeurs. On peut donc utiliser, pour traiter des cancers, de tels composés organométalliques qui présentent en outre une activité anticancéreuse accrue lorsqu'ils sont administrés en conjonction avec des facteurs intensifiant la glycolyse, telle que l'hyperglycémie et/ou l'hyperthermie, ou avec des agents anticancéreux et/ou une radiothérapie.
Bubnovskaya Larisa
Levitin Ilia
Osinsky Sergei
Tsikalova Marina
Vol'pin Mark
Cancer Research Institute
Swabey Ogilvy Renault
LandOfFree
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