Use of activated trap for screening for specific inhibitor...

Details Use of activated trap for screening for specific inhibitor... Use of activated trap for screening for specific inhibitor...

C - Chemistry, Metallurgy

12

Q

C12Q 1/42 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2351872

The invention relates to the use of activated TRAP (tartrate-resistant and purple acid phosphatases) for screening for specific inhibitor of TRAP activity useful in the treatment of diseases or degenerative conditions resulting in increased bone resorption, such as tissue damages, bone metabolic disorders, osteoporosis. TRAP can be activated by proteolytic activation of TRAP e.g. by cleaving with a protease, papain-like enzyme.

L'invention concerne l'utilisation de phosphatases acides résistant au tartrate (TRAP) servant à la recherche d'inhibiteurs spécifiques de l'activité TRAP qui conviennent pour le traitement de maladies ou de pathologies dégénératives ayant comme conséquences une résorption osseuse accrue, telles que des lésions tissulaires, des troubles du métabolisme osseux ou l'ostéoporose. Les phosphatases acides résistant au tartrate peuvent être activées par action protéolytique, par clivage à l'aide d'une protéase de type papaïne.

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