Use of adefovir or tenofovir for inhibiting mmtv-like...

Details Use of adefovir or tenofovir for inhibiting mmtv-like... Use of adefovir or tenofovir for inhibiting mmtv-like...

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61K 45/06 (2006.01) A61P 1/16 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2553455

The active metabolites of adefovir and tenofovir (PMEApp and PMPApp) are active against the MMTV RT. They are 25-fold more potent than 3TCppp, suggesting that tenofovir and adefovir may be effective at inhibiting the MMTV- like retroviruses, which may be the etiological agents involved in PBC and breast cancer.

Les métabolites actifs d'adéfovir et de ténofovir (PMEApp et PMPApp) sont actifs contre MMTV RT. Ils sont 25 fois plus puissants que 3TCppp, ce qui signifie que le ténofovir et l'adéfovir peuvent être utilisés pour inhiber les rétrovirus de type MMTV, qui peuvent être les agents étiologiques impliqués dans la cirrhose biliaire primitive et le cancer du sein.

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