A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) A61K 51/00 (2006.01) A61P 13/12 (2006.01)
Patent
CA 2655016
The present invention relates to pharmaceutical combinations comprising a therapeutically effective amount of at least one selective adenosine A1 antagonist and at least one radiocontrast media. In particular, the present invention relates to pharmaceutical combinations comprising 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-trans-cyclohexanol methanesulfonate and/or (4S)-4-hydroxy-1-(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-L- prolinamide methanesulfonate as selective adenosine A1 antagonists and at least one radiocontrast media. The invention also relates to the use of said combinations in the manufacture of a medicament for the treatment of radiocontrast media induced nephropathy. Furthermore, the invention is relating to a kit comprising a therapeutically effective amount of said combination of at least one selective adenosine A1 antagonist and at least one radiocontrast media.
La présente invention concerne des combinaisons pharmaceutiques comprenant une dose thérapeutiquement efficace d'au moins un antagoniste sélectif de l'adénosine A1 et d'au moins une substance de contraste radiologique. En particulier, la présente invention concerne des combinaisons pharmaceutiques comprenant 4-[(2-phényl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-trans-cyclohexanol méthanesulfonate et/ou (4S)-4-hydroxy-1-(2-phényl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-L- prolinamide méthanesulfonate en tant qu'antagonistes sélectifs de l'adénosine A1, et au moins une substance de contraste radiologique. L'invention concerne également l'utilisation desdites combinaisons pour la fabrication d'un médicament destiné au traitement des néphropathies induites par une substance de contraste radiologique. De plus, l'invention concerne un kit comprenant une dose thérapeutiquement efficace de ladite combinaison d'au moins un antagoniste sélectif de l'adénosine A1 et d'au moins une substance de contraste radiologique.
Fischer Yvan
Hocher Berthold
Witte Klaus
Ziegler Dieter
Mccarthy Tetrault Llp
Solvay Pharmaceuticals Gmbh
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