Use of adenosine receptor agonists in therapy

Details Use of adenosine receptor agonists in therapy Use of adenosine receptor agonists in therapy

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A61P 21/02 (2006.01) A61P 25/08 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2514848

Use of compounds of formula: (I) wherein R is C1-4 alkoxy and X is H or OH; for the prevention, treatment, or amelioration of cancer, inflammation, auto- immune disease, ischemia-reperfusion injury, epilepsy, sepsis, septic shock, neurodegeneration (including Alzheimer's Disease), muscle fatigue or muscle cramp is described. The compounds are effective at very low doses, and so can be administered at doses at which serious side effects are not observed.

La présente invention a trait à des composés de formule (I), dans laquelle R est alcoxy en C¿1?-C¿4? et X est H ou OH, pour la prévention, le traitement, ou l'amélioration du cancer, de l'inflammation, de maladie auto-immune, de la lésion de retour de la perfusion ischémique, de l'épilepsie, de la sepsie, du choc septique, de la neurodégénérescence (y compris la maladie d'Alzheimer), de la fatigue musculaire ou de crampe musculaire. Les composés sont efficaces en très petites doses, et peuvent être administrés en des doses pour lesquelles il n'y a pas d'effets secondaires notables.

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