Use of adipose tissue-derived stromal cells for chondrocyte...

Details Use of adipose tissue-derived stromal cells for chondrocyte... Use of adipose tissue-derived stromal cells for chondrocyte...

C - Chemistry, Metallurgy

12

N

C12N 5/077 (2010.01) A61K 35/12 (2006.01) A61K 35/32 (2006.01) A61L 27/38 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2316413

Methods and compositions for directing adipose-derived stromal cells cultivated in vireo to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose- derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.

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