Use of adnf polypeptides for treating peripheral neurotoxicity

A - Human Necessities – 61 – K

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Details

A61K 38/18 (2006.01) A61K 45/08 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2602893

This invention relates to the use of ADNF polypeptides in the treatment of neurotoxicity induced by chemical agents or by disease processes. The ADNF polypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences such as NAP and SAL, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites.

L'invention concerne l'utilisation de polypeptides ADNF dans le traitement de la neurotoxicité induite par des agents chimiques ou par des processus pathologiques. Ces polypeptides ADNF comprennent les polypeptides ADNF I et ADNF III (également appelés ADNP), des analogues, des sous-séquences telles que NAP et SAL et des versions de D-aminoacides (peptides de D-aminoacides en totalité ou peptides de D-aminoacides et de L-aminoacides mélangés) ainsi que des combinaisons correspondantes contenant leurs sites actifs respectifs.

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