Use of aggregated proteins to prolong retention time of a...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 9/16 (2006.01) A61K 47/42 (2006.01) A61K 51/12 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2131032

2131032 9316735 PCTABS00025 A method of prolonging the amount of time it takes for the system of a living being to remove a therapeutically effective agent from a targeted site in the living being, such as in a tumor or tumor bearing region. The method comprises the steps of selecting particles of an aggregated protein, such as macro aggregated albumin. The protein particles are provided to the targeted site in the living being. A therapeutically effective agent, such as colloidal radioactive phosphorous, is then provided to the targeted site in the living being. In an alternative embodiment, the therapeutically effective agent may be mixed with a second aliquot of the aggregated protein particles to produce a mixture thereof. The mixture is then provided to the targeted site in the living being. The aggregated protein may be any suitable protein such as albumin, gamma globulin or peptides having a particle size of approximately 10 to 70 micrometers. In a preferred embodiment, the targeted site is the tumor itself.

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