Use of agonists or antagonists of p2 purinoceptors for the...

Details Use of agonists or antagonists of p2 purinoceptors for the... Use of agonists or antagonists of p2 purinoceptors for the...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/53 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2224293

Use of agonists or antagonists of P2 purinoceptors for the prevention of glutamate-evoked cytotoxicity and in particular use of Basilen Blue E-3G (Reactive Blue 2), Cibacron Blue 3GA and 5-adenylylimidodiphosphate (AMPPNP). In the presence of cytotoxic concentrations of glutamate, these compounds sustain cellular survival of central nervous system (CNS) neurons, such as for example postnatal rat cerebellar granule neurons.

L'invention se rapporte à l'utilisation d'agonistes ou d'antagonistes de purinorécepteurs P¿2? pour la prévention de la cytotoxicité induite par le glutamate, et en particulier l'utilisation du bleu Basilien E-3G (Bleu réactif 2), du bleu Cibacron 3GA et du 5-adénylylimidodiphosphate (AMPPNP). Lorsqu'ils se trouvent en présence de concentrations cytotoxiques de glutamate, ces composés entretiennent la survivance cellulaire des neurones du système nerveux central, tels que, par exemple, les neurones granuleux cérébelleux du rat après la naissance.

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