Use of alanyl-aminopeptidase inhibitors and pharmaceutical...

Details Use of alanyl-aminopeptidase inhibitors and pharmaceutical... Use of alanyl-aminopeptidase inhibitors and pharmaceutical...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 31/517 (2006.01) A61K 38/05 (2006.01)

Patent

CA 2490714

The invention relates to the use of one or several alanyl-aminopeptidase inhibitors and/or enzyme inhibitors which exhibit the same substrate specificity in order to stimulate the production of TFG-.beta. 1 and the expression of TFG-.beta. 1 in and/or on lymphocyte T regulators. The invention also relates to the use of said inhibitors for preventing and/or curing autoimmune, allergic and cardiovascular diseases and to preclude the rejection of transplants. In addition, said invention relates to applications in which peptidic fragments of pathogenic autoantigens or synthetic analogues and/or specific antigenic components of pathogenic microorganisms are used.

L'invention concerne l'utilisation d'un ou de plusieurs inhibiteurs des alanyl-aminopeptidases et/ou d'enzymes présentant la même spécificité de substrat pour induire la production de TGF-.szlig. 1 et l'expression de TGF-.szlig. 1 dans et/ou sur des lymphocytes T régulateurs. L'invention concerne également l'utilisation de ces inhibiteurs pour la prévention et/ou le traitement de maladies auto-immunes, d'allergies, de l'artériosclérose, et pour empêcher les rejets de greffons. L'invention concerne en outre des utilisations desdits inhibiteurs, faisant appel en outre à des fragments peptidiques d'auto-antigènes pathogènes ou d'analogues de synthèse et/ou de composants antigéniques spécifiques de micro-organismes pathogènes.

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