Use of aldose reductase inhibitors to enhance insulin...

Details Use of aldose reductase inhibitors to enhance insulin... Use of aldose reductase inhibitors to enhance insulin...

A - Human Necessities

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A61K 31/33 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01)

Patent

CA 1310269

Abstract A method of enhancing insulin sensitivity in mammals (e.g., humans) is described. The method is based on the use of aldose reductase inhibitors to restore and preserve intracellular reduced glutathione levels, thereby enhancing the formation of insulin receptor-mixed disulfide bonds.

561908

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