Use of alkaline phosphatase for the detoxification of lps...

Details Use of alkaline phosphatase for the detoxification of lps... Use of alkaline phosphatase for the detoxification of lps...

A - Human Necessities

61

K

A61K 38/46 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2554683

The present invention provides a use for alkaline phosphatase for the manufacture of a medicament for the prevention or reduction of toxic LPS influx through a mucosal lining of a mammalian body cavity. A source of alkaline phosphatase is administered for the prophylaxis or treatment of LPS mediated or exacerbated diseases. The invention also provides compositions comprising a source of alkaline phosphatase for the prevention or reduction of (toxic) LPS influx or passage through mucosal layers.

L'invention concerne l'utilisation de phosphatase alcaline pour produire un médicament utilisé dans la prévention ou la diminution de l'afflux de LPS toxique à travers un revêtement muqueux d'une cavité corporelle de mammifère. Une source de phosphatase alcaline est administrée pour assurer la prophylaxie ou le traitement de maladies induites ou exacerbées par le LPS. L'invention concerne également des compositions comprenant une source de phosphatase alcaline pour assurer la prévention ou la diminution d'afflux de LPS (toxique) ou son passage à travers des couches de muqueuses.

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